Henning Stahlberg

Professor

+41 21 693 45 07

Dept. of Fundamental Microbiology, University of Lausanne, and Lab. of Biological Electron Microscopy, Inst. of Physics, SB, EPFL Cubotron, BSP421 CH-1015 Lausanne, Switzerland

Henning.Stahlberg@epfl.ch

About

Stahlberg is professor for Physics at the EPFL, see the LBEM,

and professor ad personam in the Faculty of Biology and Medicine, Department of Fundamental Microbiology, at the University of Lausanne, see the here.

Current Project

Method Development for Cryo-EM

The Structural Basis of Neurodegenration

The Structure and Function of Membrane Proteins, studied by Cryo-EM

Research

The laboratory of Henning Stahlberg at the EPFL is employing high-resolution electron microscopy to study neurodegeneration and membrane protein systems. To this end, the group is developing imaging technology in the areas of coherent electron diffractive imaging, single-electron illumination of biological samples, sample preparation and data analysis software systems such as focus-em.org. Stahlberg has studied various membrane protein systems by cryo-electron microscopy over the last decade, and has characterized water and ion channels, transporters, and secretion system membrane proteins, as well as protein aggregation (alpha-synuclein). The work of Stahlberg has been recognized by the NSF Career Award (USA).

Biography

Education
July 2002Habilitation (Biophysics), University of Basel, Switzerland, with Prof. Andreas Engel (Uni Basel): “Transmission Electron Microscopy of Proteins and Protein Complexes”
July 1997 Ph.D. (Structural Biology), Federal Institute of Technology (EPFL), Lausanne, Switzerland, with Prof. Jacques Dubochet (Uni Lausanne) and Prof. Horst Vogel (EPFL): “Transmission Electron Microscopy of Transmembrane Proteins”
August 1992 Diploma (Physics), Technical University, Berlin, Germany, with Prof. Ferenc Mezei (TU Berlin): “Magnetic Properties of Thin Metallic Films”
Employment
01/20 – pres. Academic Director, Dubochet Center for Imaging, EPFL and UNIL, Lausanne, Switzerland
01/20 – pres. Professor of Physics, IPHYS, SB, EPFL, Lausanne, Switzerland
01/20 – pres. Professor ad personam, Faculty of Biology and Medicine, University of Lausanne, Switzerland
04/09 – 01/21 Director of C-CINA, Full Professor (Ordinarius), Biozentrum, University of Basel, Switzerland
04/09 – 03/10 Adjunct Assoc. Professor, Mol. Cell. Biol., UC Davis, CA, USA
07/07 – 03/09 Associate Professor (tenured), Mol. Cell. Biology, UC Davis, CA, USA
08/03 - 06/07 Assistant Professor, Mol. Cell. Biology, UC Davis, CA, USA
08/02 - 07/03 Group Leader Structural Biology, Biozentrum, Uni Basel, Switzerland
01/98 - 07/02 PostDoc, Structural Biology, Biozentrum, University of Basel, Switzerland
1990 - 1991 Undergrad Researcher, Neutron Scattering, HMI, Berlin, Germany
1989 - 1990 Software Developer, IWIS Scientific Visualization Softw., Berlin, Germany
Organization of Unique Conferences
June 2014Gordon Research Conference on 3D EM, Organizer and Chair, Spain.
June 2013Gordon Research Conference on 3D EM, Co-Chair, New London, NH, USA.
Jun. 2005Gordon Research Conference on Mechanisms of Membrane Transport, Session chair for Aquaporin session, Tilton School, Tilton, NH, USA.
Organization of Repeating Conference Series
Aug. 2018, 2016, 2014, 2012, 2010, 2008: Biennial 10-day workshops: EMBO Cryo-EM workshop, co-Organizer, EMBL, Heidelberg, Germany.
Mar. 2018, 2016, 2014: Biennial 1-week workshops: Int. Symposium on Cryo‐EM 3D Image Analysis, Co-Organizer, Tahoe, CA, USA
Sept. 2017, 2016, 2015, 2014, 2013, 2012: Annual 1-week Workshops: International Workshop on Sub-Volume Averaging of Electron Tomography data, Organizer and Chair, University Basel, Switzerland. See dynamo-em.org/workshop
Aug. 2016, 2012, 2010, 2008, 2006: Biennial 1-week workshops: International Workshop on 2dx Image Processing, Organizer and Chair, University Basel, Switzerland (2010,2012), UC Davis, CA, USA (2008,2006). See 2dx.org/workshop
Nov. 2005, Mar. 2005, Nov. 2004, Jun. 2004, Mar. 2004: Quarterly 1-day workshops: Bay area cryo-EM meeting, Stanford, UC Davis, San Francisco, Santa Cruz, Berkeley, CA, USA. Organizer or co-organizer

Publication Databases

Publications

-+

Structural basis of bi...

Liu, H., Irobalieva, R., Kowal, J., ..., Ni, D., ..., Stahlberg, H., ...

(submitted), (2023)

228

Modulation of ABC...

Yu, Q., ..., Ni, D., Stahlberg, H., ...

(submitted), (2023)

227

Structure-function analysis of the cyclic ...

Sedzicki, J., Ni, D., Lehmann, F., Stahlberg, H., Dehio, C.

(submitted), (2023)

226

Distinct ultrastructural phenotypes of glial and neuronal ...

Böing, C., Di Fabrizio, M., Burger, D., Bol, J.G.J., Huisman, E., Rozemuller, A.J.M., van de Berg, W.D.J., Stahlberg, H., Lewis, A.

(submitted), (2023)

225

Structural basis of TRPM4 inhibition by ...

Ekundayo, B., Aruliampalam, P., Hämmerli, A.-F., Guichard, S., Boukenna, M., Rougier, J.-S., Abriel, H., Stahlberg, H., Ni, D.

(submitted), (2023)

224

Computational drug development for membrane protein targets

Li, H., Sun, X., Cui, W., Xu, M., Dong, J., Ekundayo, B., Ni, D., Rao, Z., Stahlberg, H., Yuan, S., Vogel, H.

Nature Biotechnology (in press), (2023)

223

Structure of a membrane-bound menaquinol:organohalide oxidoreductase

Cimmino, L., Duarte, A., Ni, D., Ekundayo, B., Pereira, I.A.C., Stahlberg, H., Holliger, C., Maillard, J.

Nature Communications 14(7038), (2023)

DOI: DOI

222

Structural basis of the allosteric inhibition of human ABCG2 by nanobodies

Irobalieva, R.N., Manolaridis, I., Jackson, S.M., Ni, D., Pardon, E., Stahlberg, H., Steyaert, J., Locher, K.P.

J. Mol. Biol. 435(19), 168234 (2023)

PubMed

DOI: DOI

221

Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates

Limorenko, G., Tatli, M., Kolla, R., Nazarov, S., Weil, M.T., Schöndorf, D.C., Geist, D., Reinhardt, P., Ehrnhoefer, D.E., Stahlberg, H., Gasparini, L., Lashuel, H.A.

Nature Communications 14(3939), (2023)

DOI: DOI

220

Lossless cryo-grid preparation stage for high-resolution electron microscopy

Arnold, S., Braun, T., Stahlberg, H.

US Patent 11,442,074, (2022)

219

Machine Learning in Protein Science De Novo Design of Site-Specific Protein Binders Using Surface Fingerprints

Van Hall-Beauvais, A., Gainza, P., Wehrle, S., Scheck, A., Marchand, A., Harteveld, Z., Goverde, C., Ni, D., Shuguang, T., Turelli, P., Trono, D., Stahlberg, H., Gao, G., Bronstein, M., Correia, B.

Protein Science 32(1), S106 (2023)

DOI: DOI

218

Activation mechanism of a short argonaute-TIR antiviral defense system

Ni, D., Lu, X., Stahlberg, H., Ekundayo, B.

Science Advances 9(29), eadh9002 (2023)

PubMed

DOI: DOI

217

De novo design of protein interactions with learned surface fingerprints

Gainza, P., Wehrle, S., ..., Ni, D., ..., Fierz, B., Trono, D., Stahlberg, H., Bronstein, M., Correia, B.E.

Nature 617(5759), 176-184 (2023)

PubMed

DOI: DOI

216

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

Ni, D., Turelli, P., Beckert, B., Nazarov, S., Uchikawa, E., Myasnikov, A., Pojer, F., Trono, D., Stahlberg, H., Lau, K.

PLoS Pathogens 19(4), e1011206 (2023)

PubMed

DOI: DOI

215

Structural insights into the regulation of Cas7-11 by TPR-CHAT

Ekundayo, B., Torre, D., Beckert, B., Nazarov, S., Myasnikov, A., Stahlberg, H., Ni, D.

Nature Struct. Mol. Biol. 30(2), 135-139 (2023)

PubMed

DOI: DOI

214

Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools

Hu, C., Ni, D., Nam, K.H., Majumdar, S., McLean, J., Stahlberg, H., Terns, M.P., Ke, A.

Molecular Cell 82(15), 2754-2768 (2022)

PubMed

DOI: DOI

213

Cryo-EM structure of alpha-synuclein fibrils amplified by PMCA from PD and MSA patient brains

Burger, D., Fenyi, A., Bousset, L., Stahlberg, H., Melki, R.

bioRxiv 2021.07.08.451588, (2022)

DOI: DOI

212

Mechanism of cyclic Beta-glucan export by ABC transporter Cgt of Brucella

Sedzicki, J., Ni, D., Lehmann, F., Wu, N., Zenobi, R., Jung, S., Stahlberg, H., Dehio, C.

Nature Struct. Mol. Biol. 29(12), 1170-1177 (2022)

PubMed

DOI: DOI

211

2.4 Å structure of the double ring Gemmatimonas phototrophica photosystem

Qian, P., Gardiner, A.T., Simova, I., Naydenova, K., Croll, T.I., Jackson, P.J., Nupur, Kloz, M., ?ubáková, P., Kuzma, M., Zeng, Y., Castro-Hartmann. P., Knippenberg, B.v., Goldie, K., Kaftan, D., et al., Stahlberg, H., Sobotka, R., Russo, C.J., Polivka, T., Hunter, C.N., Koblizek, M.

Science Advances 8(7), eabk3139 (2022)

DOI: DOI

210

Trans-seeding of Alzheimer’s-related tau protein by a yeast prion

Flach, M., Leu, C., Martinisi, A., Skachokova, Z., Frank, S., Tolnay, M., Stahlberg, H., Winkler, D.

Alzheimer's Dementia 18(12), 2481-2492 (2022)

PubMed

DOI: DOI

209

Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

Fenwick, C., Turelli, P., Ni, D., Perez, L., Lau, K., ..., Leyssen, P., Lévy, Y., Pojer, F., Stahlberg, H., LeGrand, R., Trono, D., Pantaleo, G.

Nature Microbiology 7(9), 1376-1389 (2022)

PubMed

DOI: DOI

208

Structural analysis of the Spike of the Omicron SARS-COV-2 variant by cryo-EM and implications for immune evasion

Ni, D., Lau, K., Turelli, P., Raclot, C., Beckert, B., Nazarov, S., Pojer, F., Myasnikov, A., Stahlberg, H., Trono, D.

bioRxiv 2021.12.27.474250, (2022)

DOI: DOI

207

FTLD-TDP assemblies seed neoaggregates with subtype-specific features via a prion-like cascade

De Rossi, P., Lewis, A., Furrer, J., De Vos, L., Demeter, T., Zbinden, A., Zhong, W., Wiersma, V.I., Scialo, C., Weber, J., Guo, Z., Scaramuzza, S., Di Fabrizio, M., Böing, C., Castano-Diez, D., Al-Amoudi, A., Pérez-Berlanga, M., Lashley, T., Stahlberg, H., Polymenidou, M.

EMBO Rep. 22(12), e53877 (2021)

PubMed

206

Structural strains of misfolded tau protein define different diseases

Stahlberg, H., Riek, R.

Nature 598(7880), 264-265 (2021)

205

Cryo-EM structure of native human thyroglobulin

Adaixo, R., Steiner, E.M., Righetto, R., Schmidt, A., Stahlberg, H., Taylor, N.

Nature Comm. 13(1), 61 (2022)

DOI: bioRxiv

204

Identification of a Dps contamination in Mitomycin-C-induced expression of Colicin Ia

Pipercevic, J., Jakob, R.P., Righetto, R., Goldie, K., Stahlberg, H., Maier, T., Hiller, S.

Biochim. Biophys. Acta Biomembr. 1863(7), 183607 (2021)

PubMed

DOI: BBAB

203

Structural basis of drug recognition by the multidrug transporter ABCG2

Kowal, J., Ni, D., Jackson, S.M., Manolaridis, I., Stahlberg, H., Locher, K.P.

J. Mol. Biol. 433(13), 166980 (2021)

PubMed

DOI: bioRxiv

202

Structures of ABCG2 under turnover conditions reveal a key step in drug transport mechanism

Yu, Q., Ni, D., Kowal, J., Manolaridis, I., Jackson, S.M., Stahlberg, H., Locher, K.P.

Nature Comm. 12(4376), (2021)

PubMed

DOI: bioRxiv

201

Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation

Botte, M., Ni, D., Schenck, S., Zimmermann, I., Chami, M., Bocquet, N., Egloff, P., Bucher, D., Trabuco, M., Cheng, R.K.Y., Brunner, J.D., Seeger, M.A., Stahlberg, H., Hennig, M.

Nature Communications 13(1), 1826 (2022)

DOI: DOI

200

Structural and molecular determinants for the interaction of ExbB from Serratia marcescens and HasB, a TonB paralog

Biou, V., Adaixo, R., Chami, M., Coureux. P., Laurent B., Ntsogo, Y., Cardoso de Amorim, G., Izadi-Pruneyre, N., Malosse, C., Chamot-Rooke, J., Stahlberg, H., Delepelaire, P.

Commun. Biol. 5(1), 355 (2022)

DOI: DOI

199

Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation

Botte, M., Ulrich, A.K.C., Adaixo, R., Gnutt, D., Brockmann, A., Bucher, D., Chami, M., Bocquet, N., Ebbinghaus-Kintscher, U., Puetter, V., Becker, A., Egner, U., Stahlberg, H., Hennig, M., Holton, S.J.

bioRxiv , 2020.10.13.334797 (2020)

DOI: DOI

198

Structural investigation of ACE2 dependent disassembly of the trimeric SARS-CoV-2 Spike glycoprotein

Ni, D., Lau, K., Lehmann, F., Fränkl, A., Hacker, D., Pojer, F., Stahlberg, H.

bioRxiv 2020.10.12.336016, (2020)

197

Alterations in sub-axonal architecture between normal aging and Parkinson's diseased human brains using label-free cryogenic X-ray nanotomography

Tran, H.T., Tsai, E.H.R., Lewis, A., Moors, T., Bol, J.G.J.M., Rostami, I., Diaz, A., Joker, A.J., Guizar-Sicairos, M., Raabe, J., Stahlberg, H., van de Berg, W.D.J., Holler, M., Shahmoradian, S.

Frontiers in Neuroscience 14(570019), (2020)

PubMed

DOI: DOI

196

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

Isaikina, P., Tsai, C.-J., Dietz, N.B., Pamula, F., Grahl, A., Goldie, K., Guixa-Gonzalez, R., Schertler, G.F.X., Hartley, O., Stahlberg, H., Maier, T., Deupi, X., Grzesiek, S.

Science Adv. 7:eabg8685, (2021)

DOI: Sci. Adv.

195

Coordination-Driven Monolayer-to-Bilayer Transition in Two-Dimensional Metal-Organic Networks

Moradi, M., Opara, N., Housecroft, C., Tulli, L., Stahlberg, H., Jung, T., Shahgaldian, P.

J. Phys. Chem. 125(16), 4204-4211 (2021)

PubMed

DOI: J. Phys. Chem.

194

Architecture of the centriole cartwheel-containing region revealed by cryo-electron tomography

Klena, N., Le Guennec, M., Tassin, A.M., Van den Hoek, H., Erdmann, P.S., Schaffer, M., Geimer, S., Aeschlimann. G., Kovacik, L., Goldie, K., Sadian, Y., Stahlberg, H., Engel, B.D., Hamel, V., Guichard, P.

EMBO J. e106246, 1-7 (2020)

PubMed

DOI: DOI

193

Single particle analysis for high resolution 2D electron crystallography

Righetto, R., Stahlberg, H.

Methods in Mol. Biology. 2215, 267-284 (2021)

PubMed

DOI: DOI

192

Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody

Sears, A.E., Albiez, S., Gulati, S., Wang, B., Kiser, P., Kovacik, L., Engel, A., Stahlberg, H., Palczewski, K.

FASEB J. 34(10), 13918-13934 (2020)

PubMed

DOI: DOI

191

Structural basis of Focal Adhesion Kinase activation on lipid membranes

Acebrón, I., Righetto, R., Schoenherr, C., de Buhr, S., Redondo, P., Culley, J., Rodríguez, C.F., Daday, C., Biyani, N., Llorca, O., Byron, A., Chami, M., Gräter. F., Boskovic J., Frame, M.C., Stahlberg, H., Lietha, D.

EMBO J. 39(e104743), (2020)

DOI: DOI

190

Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody

M. Geiger, K.-G. Stubenrauch, J. Sam, W.F. Richter, G. Jordan, J. Eckmann, C. Hage, V. Nicolini, A. Freimoser-Grundschober, M. Ritter, M.E. Lauer, Stahlberg, H., Ringler, P., J. Patel, E. Sullivan, S. Grau-Richards, S. Endres, S. Kobold, P. Umaña, P. Brünker, C. Klein

Nature Commun. 11(1), 3196 (2020)

DOI: DOI

189

The Contorsbody, an antibody format for agonism: design, structure, and function

Georges, G.J., Dengl, S., Bujotzek, A., Hesse, F., Fischer, J.A.a., Gärtner, A., Benz, J., Lauer, M.E., Ringler, P., Stahlberg, H., Plath, F., Brinkmann, U., Imhof-Jung, S.

Comp. Struct. Biol. J. 18, 1210-1220 (2020)

DOI: DOI

188

High-resolution cryo-EM structure of urease from the pathogen Yersinia enterocolitica

Righetto, R., Anton, L., Rima, L., Jakob, R.P., Zivanov, J., Mahi, M.-A., Ringler, P., Schwede, T., Maier, T., Stahlberg, H.

Nature Commun. 11, 5101 (2020)

DOI: Nature Comm.

187

Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice

Ruskamo, S., Krokengen, O.C., Kowal, J., Nieminen, T., Lehtimäki, M., Raasakka, A., Dandey, V., Vattulainen, I., Stahlberg, H., Kursula, P.

J. Biol. Chemistry 295(26), 8692-8705 (2020)

PubMed

DOI: DOI

186

New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy

Guerrero Ferreira, R., Kovacik, L., Ni, D., Stahlberg, H.

Current Opinion in Neurobiology 61, 89-95 (2020)

PubMed

DOI: DOI

185

Grayscale e-beam lithography: Effects of a delayed development for well-controlled 3D patterning

Mortelmans, T., Kazasiz, D., Guzenko, V.A., Padeste, C., Braun, T., Stahlberg, H., Li, X., Ekinci, Y.

Microelectronic Engineering 225, 111272 (2020)

DOI: DOI

184

DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity

Sustmann, C., Dickopf, S., Regula, J.T., Kettenberger, H., Mølhøj, M., Gassner, C., Weininger, D., Fenn, S., Manigold, T., Kling, L., Künkele, K.P., Schwaiger, M., Bossenmaier, B., Griese, J.J., Hopfner, K.P., Graff, A., Stahlberg, H., Ringler, P., Lauer, M.E., Brinkmann, U., Schaefer, W., Klein, C.

MAbs 11(8), 1402-1414 (2019)

PubMed

DOI: DOI

183

Diverse roles of TssA-like proteins in the assembly of bacterial type VI secretion systems

Schneider, J.P., Nazarov, S., Liuzzo, M., Ringel, P.D., Stahlberg, H., Basler, M.

EMBO J. 38: e100825, 1-17 (2019)

PubMed

DOI: DOI

182

A helical inner scaffold provides a structural basis for centriole cohesion

Le Guennec, M., Klena, N., Gambarotto, D., Laporte, M.H., Tassin, A.M., van den Hoek, H., Erdmann, P.S., Schaffer, M., Kovacik, L., Borgers, S., Goldie, K., Stahlberg, H., Bornens, M., Azimzadeh, J., Engel, B.D., Hamel, V., Guichard, P.

Science Advances 6(7), eaaz4137 (2020)

PubMed

DOI: DOI

181

Inner-membrane GspF of the bacterial type II secretion system is a dimeric adaptor mediating pseudopilus biogenesis

Van Putte, W., De Vos, T., Vanden Broeck, W., Stahlberg, H., Kudryashev, M., Savvides, S.N.

bioRxiv 435982, (2020)

180

Two new polymorphic structures of alpha-synuclein solved by cryo-electron microscopy

Guerrero Ferreira, R., Taylor, N., Arteni, A.-A., Kumari, P., Mona, D., Ringler, P., Britschgi, M., Lauer, M.E., Verasdock, J., Riek, R., Melki, R., Meier, B.H., Böckmann, A., Bousset, L., Stahlberg, H.

eLife 8:e48907, (2019)

PubMed

DOI: DOI

179

Cryo-EM structure of the rhodopsin-G-alpha-i-beta-gamma complex reveals binding of the rhodopsin C-terminal tail to the G-beta subunit

Tsai, C.J., Marino, J., Adaixo, R., Pamula, F., Muehle, J., Maeda, S., Flock, T., Taylor, N., Mohammed, I., Matile, H., Dawson, R.J.P., Deupi, X., Stahlberg, H., Schertler, G.F.X.

eLife 8;e46041, (2019)

PubMed

DOI: DOI

178

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes

Shahmoradian, S., Lewis, A., Genoud, C., Graff, A., Pérez Navarro, P., Goldie, K., Sütterlin, R., Castano-Diez, D., Ingrassia, A., Rozemuller, A.J.M., Paepe, A.D., Erny, J.Staempfli, A., Hoernschemeyer, J., Niedieker, D., El-Mashtoly, S.F., Gerwert, K., Bohrmann, B., Britschgi, M., Stahlberg, H., van de Berg, W.D.J., Lauer, M.E.

Nature Neuroscience 22, 1099-1109 (2019)

PubMed

DOI: Nature Neurosc.

177

‘Differential visual proteomics’: Enabling the proteome-wide comparison of protein structures of single-cells

Syntychaki, A., Rima, L., Schmidli, C., Stohler, T., Bieri, A., Sütterlin, R., Stahlberg, H., Castano-Diez, D., Braun, T.

J. of Proteome Research 18(9), 3521-3531 (2019)

PubMed

DOI: DOI

176

Part 2: Coping with Biology

Benjamin Stecher. (Images:, Lewis, A., Shahmoradian, S., Stahlberg, H., )

Tomorrow Edition (an online blog by Benjamin Stecher about his journey in Parkinson's disease), (2018)

DOI: Tomorrow Edition

175

Imaging of post-mortem human brain tissue using electron and X-ray microscopy

Lewis, A., Genoud, C., Pont, M., van de Berg, W.D.J., Frank, S., Stahlberg, H., Shahmoradian, S., Al-Amoudi, A.

Current Opinion Structural Biology 58, 138-148 (2019)

PubMed

DOI: DOI

174

Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy

Claus, C., Ferrara, C., Xu, W., Sam, J., Lang, S., Uhlenbrock, F., Albrecht, R., Herter, S., Schlenker, R., Hüsser, T., Diggelmann, S., Challier, J., Mössner, E., Hosse, RJ., Hofer, T., Brünker, P., Joseph, C., Benz, J., Ringler, P., Stahlberg, H., Lauer, M., et al., Klein, C., Umana, P.

Science Translational Medicine 11(496), 1-12 (2019)

PubMed

DOI: DOI

173

Microfluidic protein isolation and sample preparation for high resolution cryo-EM

Schmidli, C., Albiez, S., Rima, L., Righetto, R., Mohammed, I., Oliva, P., Kovacik, L., Stahlberg, H., Braun, T.

PNAS 116(30), 15007-15012 (2019)

PubMed

DOI: PNAS

172

Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin

Piper, S., Brillault, L., Rothnagel, R., Croll, T., Box, J., Chassagnon, I., Scherer, S., Goldie, K., Jones, S., Schepers, F., Hartley-Tassell, L., Ve, T., Busby, J., Dalziel, J., Lott, S., Hankamer, B., Stahlberg, H., Hurst, M., Landsberg, M

Nature Communications 10(1), 1952 (2019)

PubMed

DOI: DOI

171

Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases

Gulati, S., Palczewski, K., Engel, A., Stahlberg, H., Kovacik, L.

Science Advances 5(2), eaav4322 (2019)

PubMed

DOI: DOI

170

Self-assembly of a designed nucleoprotein architecture through multimodal interactions

Subramanian, R.H., Smith, S.J., Alberstein, R.G., Bailey, J.B., Zhang, L., Cardone, G., Suominen, L., Chami, M., Stahlberg, H., Baker, T.S., Tezcan, F.A.

ACS Central Science 4(11), 1578-1586 (2018)

PubMed

DOI: DOI

169

Retrieving high-resolution information from disordered 2D crystals by single particle cryo-EM

Righetto, R., Biyani, N., Kowal, J., Chami, M., Stahlberg, H.

Nature Communications 10(1), 1722 (2019)

PubMed

DOI: Nature Comm.

168

Molecular structure and function of myelin protein P0 in membrane stacking

Raasakka, A., Ruskamo, S., Kowal, J., Han, H., Baumann, A., Myllykoski, M., Fasano, A., Rossano, R., Riccio, P., Buerck, J., Ulrich, A.S., Stahlberg, H., Kursula, P.

Scientific Reports 9(462), (2019)

PubMed

DOI: DOI

167

TDP-43 extracted from FTLD patient brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates

Laferriere, F., Maniecka, Perez-Berlanga, Hruska-Plochan, Gilhespy, Hock, Wagner, Afroz, Boersema, Barmettler, Foti, Asi, Isaacs, Al-Amoudi, A., Lewis, A., Stahlberg, H., Ravits, De Giorgi, Ichas, Bezard, Picotti, P., Lashley, T., Polymenidou, M.

Nature Neuroscience 22, 65-77 (2019)

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Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

Manolaridis, I., Jackson, S.M., Taylor, N., Kowal, J., Stahlberg, H., Locher, K.

Nature 563(7731), 426-430 (2018)

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Protocols for Subtomogram Averaging of Membrane Proteins in the Dynamo Software Package

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Frontiers in Molecular Biosciences 5(82), 1-18 (2018)

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Demonstration of femtosecond X-ray pump X-ray probe diffraction on protein crystals

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An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel

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Nature Comm. 9(1), 3978 (2018)

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Structure of a PSI–LHCI–cyt b6f supercomplex in Chlamydomonas reinhardtii promoting cyclic electron flow under anaerobic conditions

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PNAS 115(41), 10517-10522 (2018)

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Cryo-EM structure of alpha-synuclein fibrils

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eLife 7(e36402), (2018)

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Structural basis for regulation of human acetyl-CoA carboxylase

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Nature 558, 470-474 (2018)

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Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

Jackson, S.M., Manolaridis, I., Kowal, J., Zechner, M., Taylor, N., Bause, M., Bauer, S., Bartholomaeus, R., Bernhardt, G., Koenig, B., Buschauer, A., Stahlberg, H., Altmann, K.H., Locher, K.P.

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Image processing techniques for high-resolution structure determination from badly ordered 2D crystals

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Journal of Structural Biology 203(2), 120-134 (2018)

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Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene

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Miniaturized sample preparation for transmission electron microscopy

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Cryo-EM reconstruction of Type VI secretion system baseplate and sheath distal end

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EMBO Journal 37, e97103 (2018)

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Miniaturizing EM Sample Preparation: Opportunities, Challenges and "Visual Proteomics"

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Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1

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MRCZ – A file format for cryo-TEM data with fast compression

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High-resolution cryo-EM structure of the cyclic nucleotide-modulated potassium channel MloK1 in a lipid bilayer

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Structure 26(1), 20-27 (2018)

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Lipid Internal Dynamics Probed in Nanodiscs

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ChemPhysChem 18(19), 2651-2657 (2017)

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Expression, Biochemistry, and Stabilization with Camel Antibodies of Membrane Proteins: Case Study of the Mouse 5-HT3 Receptor

Hassaïne, G., Deluz, C., Grasso, L., Wyss, R., Hovius, R., Stahlberg, H., Tomizaki, T., Desmyter, A., Moreau, C., Peclinovska, L., Minniberger, S., Mebarki, L., Li, X.-D.., Vogel, H., Nury, H.

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CryoEM structure of the extended type VI secretion system sheath–tube complex

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Nature Microbiology 2(11), 1507-1512 (2017)

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Three-Dimensional Imaging of Biological Tissue by Cryo X-Ray Ptychography

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Structure of the human multidrug transporter ABCG2

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Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress

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Direct protein crystallization on ultrathin membranes for diffraction measurements at X-ray free electron lasers

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Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

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Scientific Reports 7(1), 8667-8678 (2017)

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Membrane association landscape of myelin basic protein portrays formation of the myelin major dense line

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Focus: The interface between data collection and data processing in cryo-EM

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Cell-free reconstitution reveals centriole cartwheel assembly mechanisms

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Amyloid Fibril Polymorphism: Almost Identical on the Atomic Level, Mesoscopically Very Different

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Proteoliposomes - a system to study membrane proteins under buffer gradients by cryo-EM

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Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein A-I

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Biochemical and biophysical approaches to study the structure and function of the chloride channel (ClC) family of proteins

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GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

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Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels

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Thylakoid ultrastructure: Visualizing the photosynthetic machinery

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ACS Nano 10, 4981-4988 (2016)

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Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbs

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Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome

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Nature 531(7596), 598-603 (2016)

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Atomic structure of bacteriophage T4 baseplate and its function in triggering sheath contraction

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Cholesteryl ester transfer between lipoproteins does not require the formation of a ternary tunnel complex with the cholesteryl ester transfer protein

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Preparation and characterization of stable alpha-synuclein lipoprotein particles

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The structure of the mouse serotonin 5-HT3 receptor in lipid vesicles

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Structure 24(1), 165-170 (2016)

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The lipidome associated with the gamma-secretase complex is required for its integrity and activity.

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Biochemical Journal 473(3), 321-334 (2016)

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Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy

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Proc Natl Acad Sci U S A 112(43), 13237-42 (2015)

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Structure of the type VI secretion system contractile sheath

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Cell 160(5), 952-62 (2015)

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CTF challenge: result summary

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J Struct Biol 190(3), 348-59 (2015)

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Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions

Beckert, B., Kedrov, A., Sohmen, D., Kempf, G., Wild, K., Sinning, I., Stahlberg, H., Wilson, D. N., Beckmann, R.

Nat Struct Mol Biol 22(10), 767-73 (2015)

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Yersinia enterocolitica type III secretion injectisomes form regularly spaced clusters, which incorporate new machines upon activation

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Mol Microbiol 95(5), 875-84 (2015)

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Rendering graphene supports hydrophilic with non-covalent aromatic functionalization for transmission electron microscopy

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Appl Phys Lett 104(13), 134103-134107 (2014)

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2dx_automator: implementation of a semiautomatic high-throughput high-resolution cryo-electron crystallography pipeline

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J Struct Biol 186(2), 302-7 (2014)

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openBEB: open biological experiment browser for correlative measurements

Ramakrishnan, C., Bieri, A., Sauter, N., Roizard, S., Ringler, P., Müller, S., Goldie, K., Enimanev, K., Stahlberg, H., Rinn, B., Braun, T.

BMC Bioinformatics 15, 84 (2014)

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A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics

McCoy, J. G., Rusinova, R., Kim, D. M., Kowal, J., Banerjee, S., Jaramillo Cartagena, A., Thompson, A. N., Kolmakova-Partensky, L., Stahlberg, H., Andersen, O. S., Nimigean, C. M.

J Biol Chem 289(14), 9535-46 (2014)

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Single particle 3D reconstruction for 2D crystal images of membrane proteins

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J Struct Biol 185(3), 267-77 (2014)

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Structural and mechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins

Moharana, K., Zabeau, L., Peelman, F., Ringler, P., Stahlberg, H., Tavernier, J., Savvides, S. N.

Structure 22(6), 866-77 (2014)

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Clostridium difficult toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence

Schwan, C., Kruppke, A. S., Nolke, T., Schumacher, L., Koch-Nolte, F., Kudryashev, M., Stahlberg, H., Aktories, K.

Proc Natl Acad Sci U S A 111(6), 2313-8 (2014)

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Review: Cryo-electron microscopy of membrane proteins

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Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells

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Cell Rep 9(3), 810-21 (2014)

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The ultrastructure of Chlorobaculum tedium revealed by cryo-electron tomography

Kudryashev, M., Aktoudianaki, A., Dedoglou, D., Stahlberg, H., Tsiotis, G.

Biochim Biophys Acta 1837(10), 1635-42 (2014)

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Exploring the interactome: microfluidic isolation of proteins and interacting partners for quantitative analysis by electron microscopy

Giss, D., Kemmerling, S., Dandey, V., Stahlberg, H., Braun, T.

Anal Chem 86(10), 4680-7 (2014)

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Functional surface engineering by nucleotide-modulated potassium channel insertion into polymer membranes attached to solid supports

Kowal, J.L., Kowal, J., Wu, D., Stahlberg, H., Palivan, C. G., Meier, W. P.

Biomaterials 35(26), 7286-94 (2014)

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X-ray structure of the mouse serotonin 5-HT3 receptor

Hassaine, G., Deluz, C., Grasso, L., Wyss, R., Tol, M. B., Hovius, R., Graff, A., Stahlberg, H., Tomizaki, T., Desmyter, A., Moreau, C., Li, X. D., Poitevin, F., Vogel, H., Nury, H.

Nature 512(7514), 276-81 (2014)

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Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1

Kowal, J., Chami, M., Baumgartner, P., Arheit, M., Chiu, P. L., Rangl, M., Scheuring, S., Schroder, G. F., Nimigean, C. M., Stahlberg, H.

Nat Commun 5, 3106 (2014)

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Microfluidics to isolate untagged proteins from cell extracts for visual analysis by electron microscopy

D. Giss, S. Kemmerling, Dandey, V., Stahlberg, H., Braun, T.

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Single-cell lysis for visual analysis by electron microscopy

Kemmerling, S., Arnold, S., Bircher, B. A., Sauter, N., Escobedo, C., Dernick, G., Hierlemann, A., Stahlberg, H., Braun, T.

J Struct Biol 183(3), 467-73 (2013)

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Automation of image processing in electron crystallography

Arheit, M., Castano-Diez, D., Thierry, R., Gipson, B., Zeng, X., Stahlberg, H.

Methods Mol Biol 955, 313-30 (2013)

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Structure and substrate-induced conformational changes of the secondary citrate/sodium symporter CitS revealed by electron crystallography

Kebbel, F., Kurz, M., Arheit, M., Grütter, M. G., Stahlberg, H.

Structure 21(7), 1243-50 (2013)

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Structure of the dodecameric Yersinia enterocolitica secretin YscC and its trypsin-resistant core

Kowal, J., Chami, M., Ringler, P., Müller, S., Kudryashev, M., Castano-Diez, D., Amstutz, M., Cornelis, G. R., Stahlberg, H., Engel, A.

Structure 21(12), 2152-61 (2013)

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Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast

Lemgruber, L., Kudryashev, M., Dekiwadia, C., Riglar, D. T., Baum, J., Stahlberg, H., Ralph, S. A., Frischknecht, F.

Malar J 12, 25 (2013)

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Thermal unfolding of a mammalian pentameric ligand-gated ion channel proceeds at consecutive, distinct steps

Tol, M. B., Deluz, C., Hassaine, G., Graff, A., Stahlberg, H., Vogel, H.

J Biol Chem 288(8), 5756-69 (2013)

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Image processing of 2D crystal images

Arheit, M., Castano-Diez, D., Thierry, R., Gipson, B., Zeng, X., Stahlberg, H.

Methods Mol Biol 955, 171-94 (2013)

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89

Vaccinia virus entry is followed by core activation and proteasome-mediated release of the immunomodulatory effector VH1 from lateral bodies

Schmidt, F. I., Bleck, C. K., Reh, L., Novy, K., Wollscheid, B., Helenius, A., Stahlberg, H., Mercer, J.

Cell Rep 4(3), 464-76 (2013)

PubMed

88

In situ structural analysis of the Yersinia enterocolitica injectisome

Kudryashev, M., Stenta, M., Schmelz, S., Amstutz, M., Wiesand, U., Castano-Diez, D., Degiacomi, M. T., Munnich, S., Bleck, C. K., Kowal, J., Diepold, A., Heinz, D. W., Dal Peraro, M., Cornelis, G. R., Stahlberg, H.

Elife 2, e00792 (2013)

PubMed

87

Merging of image data in electron crystallography

Arheit, M., Castano-Diez, D., Thierry, R., Abeyrathne, P., Gipson, B., Stahlberg, H.

Methods Mol Biol 955, 195-209 (2013)

PubMed

86

Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism

Degiacomi, M. T., Iacovache, I., Pernot, L., Chami, M., Kudryashev, M., Stahlberg, H., van der Goot, F. G., Dal Peraro, M.

Nat Chem Biol 9(10), 623-9 (2013)

PubMed

85

The application of graphene as a sample support in transmission electron microscopy

Pantelic, R., Meyer, J.C., Kaiser, U., Stahlberg, H.

Solid State Commun 152(15), 1375-1382 (2012)

DOI: 10.1016/j.ssc.2012.04.038

84

Electron microscopy analysis of 2D crystals of membrane proteins

Abeyrathne, P., Arheit, M., Kebbel, F., Castano-Diez, D., Goldie, K., Chami, M., Relault, L., Kühlbrandt, W., Stahlberg, H.

Comprehensive Biophysics 1, 277-310 (2012)

DOI: 10.1016/B978-0-12-374920-8.00119-3

83

Projection structure of the secondary citrate/sodium symporter CitS at 6 Å resolution by electron crystallography

Kebbel, F., Kurz, M., Grütter, M. G., Stahlberg, H.

J Mol Biol 418(42006), 117-26 (2012)

PubMed

82

RNAi screening reveals proteasome- and Cullin3-dependent stages in vaccinia virus infection

Mercer, J., Snijder, B., Sacher, R., Burkard, C., Bleck, C. K., Stahlberg, H., Pelkmans, L., Helenius, A.

Cell Rep 2(4), 1036-47 (2012)

PubMed

81

Assessing the benefits of focal pair cryo-electron tomography

Kudryashev, M., Stahlberg, H., Castano-Diez, D.

J Struct Biol 178(2), 88-97 (2012)

PubMed

80

Structural basis for chirality and directional motility of Plasmodium sporozoites

Kudryashev, M., Munter, S., Lemgruber, L., Montagna, G., Stahlberg, H., Matuschewski, K., Meissner, M., Cyrklaff, M., Frischknecht, F.

Cell Microbiol 14(11), 1757-68 (2012)

PubMed

79

Structure and function of purified monoclonal antibody dimers induced by different stress conditions

Paul, R., Graff, A., Stahlberg, H., Lauer, M. E., Rufer, A. C., Beck, H., Briguet, A., Schnaible, V., Buckel, T., Boeckle, S.

Pharm Res 29(8), 2047-59 (2012)

PubMed

78

Characterization of the motion of membrane proteins using high-speed atomic force microscopy

Casuso, I., Khao, J., Chami, M., Paul-Gilloteaux, P., Husain, M., Duneau, J. P., Stahlberg, H., Sturgis, J. N., Scheuring, S.

Nat Nanotechnol 7(8), 525-9 (2012)

PubMed

77

Connecting micro-fluidics to electron microscopy

Kemmerling, Simon, Ziegler, J., Schweighauser, G., Arnold, S., Giss, D., Müller, S., Ringler, P., Goldie, K., Goedecke, N., Hierlemann, A., Stahlberg, H., Engel, A., Braun, T.

J Struct Biol 177(1), 128-134 (2012)

PubMed

76

Dynamo: a flexible, user-friendly development tool for subtomogram averaging of cryo-EM data in high-performance computing environments

Castano-Diez, D., Kudryashev, M., Arheit, M., Stahlberg, H.

J Struct Biol 178(2), 139-51 (2012)

PubMed

75

Ionic liquids as matrices in microfluidic sample deposition for high-mass matrix- assisted laser desorption/ionization mass spectrometry

Weidmann, S., Kemmerling, S., Madler, S., Stahlberg, H., Braun, T., Zenobi, R.

Eur J Mass Spectrom (Chichester, Eng) 18(3), 279-86 (2012)

PubMed

74

Limiting factors in single particle cryo electron tomography

Kudryashev, M., Castano-Diez, D., Stahlberg, H.

Comput Struct Biotechnol J 1, e201207002 (2012)

PubMed

73

Mus81-Mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repair

Schwartz, E. K., Wright, W. D., Ehmsen, K. T., Evans, J. E., Stahlberg, H., Heyer, W. D.

Mol Cell Biol 32(15), 3065-80 (2012)

PubMed

72

Oxidative doping renders graphene hydrophilic, facilitating its use as a support in biological TEM

Pantelic, R., Suk, J. W., Hao, Y., Ruoff, R. S., Stahlberg, H.

Nano Lett 11(10), 4319-23 (2011)

PubMed

71

Polymer-based cell-free expression of ligand-binding family B G-protein coupled receptors without detergents

Klammt, C., Perrin, M. H., Maslennikov, I., Renault, L., Krupa, M., Kwiatkowski, W., Stahlberg, H., Vale, W., Choe, S.

Protein Sci 20(6), 1030-41 (2011)

PubMed

70

Rad51 paralogues Rad55-Rad57 balance the antirecombinase Srs2 in Rad51 filament formation

Liu, J., Renault, L., Veaute, X., Fabre, F., Stahlberg, H., Heyer, W. D.

Nature 479(7372), 245-8 (2011)

PubMed

69

Automatic recovery of missing amplitudes and phases in tilt-limited electron crystallography of two-dimensional crystals

Gipson, B., Masiel, D. J., Browning, N. D., Spence, J., Mitsuoka, K., Stahlberg, H.

Phys Rev E Stat Nonlin Soft Matter Phys 84(1 Pt 1), 11916 (2011)

PubMed

68

Graphene: Substrate preparation and introduction

Pantelic, R., Suk, J. W., Magnuson, C. W., Meyer, J. C., Wachsmuth, P., Kaiser, U., Ruoff, R. S., Stahlberg, H.

J Struct Biol 174(1), 234-8 (2011)

PubMed

67

Interaction of complexes I, III, and IV within the bovine respirasome by single particle cryo electron tomography

Dudkina, N. V., Kudryashev, M., Stahlberg, H., Boekema, E. J.

Proc Natl Acad Sci U S A 108(37), 15196-200 (2011)

PubMed

66

3D reconstruction from 2D crystal image and diffraction data

Schenk, A. D., Castano-Diez, D., Gipson, B., Arheit, M., Zeng, X., Stahlberg, H.

Methods Enzymol 482, 101-29 (2010)

PubMed

65

Preparation of 2D crystals of membrane proteins for high-resolution electron crystallography data collection

Abeyrathne, P., Chami, M., Pantelic, R., Goldie, K., Stahlberg, H.

Method Enzymol 481, 25-43 (2010)

PubMed

64

High-resolution low-dose scanning transmission electron microscopy

Buban, J. P., Ramasse, Q., Gipson, B., Browning, N. D., Stahlberg, H.

J Electron Microsc (Tokyo) 59(2), 103-12 (2010)

PubMed

63

Structural variability of edge dislocations in a SrTiO3 low-angle [001] tilt grain boundary

Buban, J.P., Chi, M., Masiel, D.J., Bradley, J.P., Jiang, B., Stahlberg, H., Browning, N.D.

J Mater Res 24, 2191-2199 (2009)

DOI: 10.1557/jmr.2009.0259

62

2007 annual progress report synopsis of the Center for Structures of Membrane Proteins

Stroud, R. M., Choe, S., Holton, J., Kaback, H. R., Kwiatkowski, W., Minor, D. L., Riek, R., Sali, A., Stahlberg, H., Harries, W.

J Struct Funct Genomics 10(2), 193-208 (2009)

PubMed

61

Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion

DeVay, R. M., Dominguez-Ramirez, L., Lackner, L. L., Hoppins, S., Stahlberg, H., Nunnari, J.

J Cell Biol 186(6), 793-803 (2009)

PubMed

60

Crystal structures of Limulus SAP-like pentraxin reveal two molecular aggregations

Shrive, A. K., Burns, I., Chou, H. T., Stahlberg, H., Armstrong, P. B., Greenhough, T. J.

J Mol Biol 386(5), 1240-54 (2009)

PubMed

59

Membrane activity of a C-reactive protein

Harrington, J. M., Chou, H. T., Gutsmann, T., Gelhaus, C., Stahlberg, H., Leippe, M., Armstrong, P. B.

FEBS Lett 583(6), 1001-5 (2009)

PubMed

58

Structure determination using electron crystallography

Evans, J.E., Renault, L., Stahlberg, H.

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57

2dx - Automated 3D structure reconstruction from 2D crystal data

Gipson, B., Zeng, X., Stahlberg, H.

Microscopy and Microanalysis 14(Supp 2), 1290-1291 (2008)

DOI: 10.1017/S1431927608081919

56

Bridging across length scales: multi-scale ordering of supported lipid bilayers via lipoprotein self-assembly and surface patterning

Vinchurkar, M. S., Bricarello, D. A., Lagerstedt, J. O., Buban, J. P., Stahlberg, H., Oda, M. N., Voss, J. C., Parikh, A. N.

J Am Chem Soc 130(33), 11164-9 (2008)

PubMed

55

The fold of alpha-synuclein fibrils

Vilar, M., Chou, H. T., Luhrs, T., Maji, S. K., Riek-Loher, D., Verel, R., Manning, G., Stahlberg, H., Riek, R.

Proc Natl Acad Sci U S A 105(25), 8637-42 (2008)

PubMed

54

Low-dose aberration corrected cryo-electron microscopy of organic specimens

Evans, J. E., Hetherington, C., Kirkland, A., Chang, L. Y., Stahlberg, H., Browning, N.

Ultramicroscopy 108(12), 1636-44 (2008)

PubMed

53

Membrane pore formation by pentraxin proteins from Limulus, the American horseshoe crab

Harrington, J. M., Chou, H. T., Gutsmann, T., Gelhaus, C., Stahlberg, H., Leippe, M., Armstrong, P. B.

Biochem J 413(2), 305-13 (2008)

PubMed

52

Molecular electron microscopy: state of the art and current challenges

Stahlberg, H., Walz, T.

ACS Chem Biol 3(5), 268-81 (2008)

PubMed

51

2dx_merge: data management and merging for 2D crystal images

Gipson, B., Zeng, X., Stahlberg, H.

J. Struct. Biol. 160(3), 375-384 (2007)

PubMed

DOI: 10.1016/j.jsb.2007.09.011

50

Editorial: Spotlight on Electron Crystallography

Hankamer, B., Glaeser, B., Stahlberg, H.

J Struct Biol 160(3), 263-264 (2007)

PubMed

DOI: 10.1016/j.jsb.2007.11.001

49

Three-dimensional electron microscopy of macromolecular assemblies (J. Frank), Book Review

Renault, L., Stahlberg, H.

Scanning 29(1), 37 (2007)

48

Oocyte CD9 is enriched on the microvillar membrane and required for normal microvillar shape and distribution

Runge, K. E., Evans, J. E., He, Z. Y., Gupta, S., McDonald, K. L., Stahlberg, H., Primakoff, P., Myles, D. G.

Dev Biol 304(1), 317-25 (2007)

PubMed

47

2dx – User-friendly image processing for 2D crystals

Gipson, B., Zeng, X., Zhang, Z. Y., Stahlberg, H.

J Struct Biol 157(1), 64-72 (2007)

PubMed

46

A maximum likelihood approach to two-dimensional crystals

Zeng, X., Stahlberg, H., Grigorieff, N.

J Struct Biol 160(3), 362-74 (2007)

PubMed

45

Automatic lattice determination for two-dimensional crystal images

Zeng, X., Gipson, B., Zheng, Z. Y., Renault, L., Stahlberg, H.

J Struct Biol 160(3), 353-61 (2007)

PubMed

44

Structural and kinetic studies of induced fit in xylulose kinase from Escherichia coli

Di Luccio, E., Petschacher, B., Voegtli, J., Chou, H. T., Stahlberg, H., Nidetzky, B., Wilson, D. K.

J Mol Biol 365(3), 783-98 (2007)

PubMed

43

Electron crystallography of membrane proteins

Chou, H. T., Evans, J. E., Stahlberg, H.

Methods Mol Biol 369, 331-43 (2007)

PubMed

42

The structure of the prokaryotic cyclic nucleotide-modulated potassium channel MloK1 at 16 A resolution

Chiu, P. L., Pagel, M. D., Evans, J., Chou, H. T., Zeng, X., Gipson, B., Stahlberg, H., Nimigean, C. M.

Structure 15(9), 1053-64 (2007)

PubMed

41

Avoiding charge induced drift in vitrified biological specimens through scanning transmission electron microscopy.

Nicotra, G., Chou, H.-T., Stahlberg, H., Browning, N.D.

Microscopy and Microanalysis 12(Supp. 02), 246-247 (2006)

DOI: 10.1017/S1431927606063070

40

Cryo-electron microscopy analysis of a 105 kDa protein particle: the xylulose kinase from E. coli

Chou, H.-T., di Luccio, E., Wilson, D., Stahlberg, H.

Microscopy and Microanalysis 12(Supp 2), 408-409 (2006)

DOI: 10.1017/S1431927606066530

39

A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assays

Tao, L., Mogilner, A., Civelekoglu-Scholey, G., Wollman, R., Evans, J., Stahlberg, H., Scholey, J. M.

Curr Biol 16(23), 2293-302 (2006)

PubMed

38

Double hexameric ring assembly of the type III protein translocase ATPase HrcN

Müller, S., Pozidis, C., Stone, R., Meesters, C., Chami, M., Engel, A., Economou, A., Stahlberg, H.

Mol Microbiol 61(1), 119-25 (2006)

PubMed

37

Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans

Evans, J. E., Snow, J. J., Gunnarson, A. L., Ou, G., Stahlberg, H., McDonald, K. L., Scholey, J. M.

J Cell Biol 172(5), 663-9 (2006)

PubMed

36

Milestones in electron crystallography

Renault, L., Chou, H. T., Chiu, P. L., Hill, R. M., Zeng, X., Gipson, B., Zhang, Z. Y., Cheng, A., Unger, V., Stahlberg, H.

J Comput Aided Mol Des 20(42193), 519-27 (2006)

PubMed

35

Applications of Atomic Scale Scanning Transmission Electron Microscopy

Browning, N.D., Erni, R., Mitterbauer, C.J., Fu, L., Chi, M., Mehraeen, S., Herrera, M., Chou, H.-T., Stahlberg, H., Ramasse, Q.M., Ziegler, A., Nicotra, G., Arslan, I., Idrobo, J.-C., Stach, E.A., Bleiloch, A.

Microscopy and Microanalysis 12(S02), 134-135 (2006)

DOI: 10.1017/S143192760606627X

34

Testing 3-D Reconstruction Methods for Electron Tomography

Mehraeen, S., Stahlberg, H., Evans, J. E., Meesters, C., Arslan, I., Midgley, P.A., Browning, N. D.

Microscopy and Microanalysis 11(S02), 336-337 (2005)

DOI: 10.1017/S1431927605508390

33

The 4.5 Å structure of human AQP2

Schenk, A. D., Werten, P. J., Scheuring, S., de Groot, B. L., Müller, S., Stahlberg, H., Philippsen, A., Engel, A.

J Mol Biol 350(2), 278-89 (2005)

PubMed

32

Oligomeric structure of the Bacillus subtilise cell division protein DivIVA determined by transmission electron microscopy

Stahlberg, H., Kutejova, E., Muchova, K., Gregorini, M., Lustig, A., Müller, S., Olivieri, V., Engel, A., Wilkinson, A. J., Barak, I.

Mol Microbiol 52(5), 1281-90 (2004)

PubMed

31

Type III protein translocase: HrcN is a peripheral ATPase that is activated by oligomerization

Pozidis, C., Chalkiadaki, A., Gomez-Serrano, A., Stahlberg, H., Brown, I., Tampakaki, A. P., Lustig, A., Sianidis, G., Politou, A. S., Engel, A., Panopoulos, N. J., Mansfield, J., Pugsley, A. P., Karamanou, S., Economou, A.

J Biol Chem 278(28), 25816-24 (2003)

PubMed

30

IPLT: An image processing library and toolkit for the electron microscopy community

Philippsen, A., Schenk, A. D., Stahlberg, H., Engel, A.

J Struct Biol 144(42006), 42106 (2003)

PubMed

29

Progress in the analysis of membrane protein structure and function

Werten, P. J., Remigy, H. W., de Groot, B. L., Fotiadis, D., Philippsen, A., Stahlberg, H., Grubmuller, H., Engel, A.

FEBS Lett 529(1), 65-72 (2002)

PubMed

28

Aquaglyceroporins: channel proteins with a conserved core, multiple functions, and variable surfaces

Engel, A., Stahlberg, H.

Int Rev Cytol 215, 75-104 (2002)

PubMed

27

Sampling the conformational space of membrane protein surfaces with the AFM

Scheuring, S., Muller, D. J., Stahlberg, H., Engel, H. A., Engel, A.

Eur Biophys J 31(3), 172-8 (2002)

PubMed

26

Assessing the structure of membrane proteins: combining different methods gives the full picture

Stahlberg, H., Engel, A., Philippsen, A.

Biochem Cell Biol 80(5), 563-8 (2002)

PubMed

25

Charting and unzipping the surface layer of Corynebacterium glutamicum with the atomic force microscope

Scheuring, S., Stahlberg, H., Chami, M., Houssin, C., Rigaud, J. L., Engel, A.

Mol Microbiol 44(3), 675-84 (2002)

PubMed

24

The aquaporin superfamily: structure and function

Stahlberg, H., Heymann, B., Mitsuoka, K., Fuyijoshi, Y., Engel, A.

Current Topics in Membranes 51, 39-119 (2001)

23

ATP synthase: constrained stoichiometry of the transmembrane rotor

Muller, D. J., Dencher, N. A., Meier, T., Dimroth, P., Suda, K., Stahlberg, H., Engel, A., Seelert, H., Matthey, U.

FEBS Lett 504(3), 219-22 (2001)

PubMed

22

Bacterial Na(+)-ATP synthase has an undecameric rotor

Stahlberg, H., Muller, D. J., Suda, K., Fotiadis, D., Engel, A., Meier, T., Matthey, U., Dimroth, P.

EMBO Rep 2(3), 229-33 (2001)

PubMed

21

Two-dimensional crystals: a powerful approach to assess structure, function and dynamics of membrane proteins

Stahlberg, H., Fotiadis, D., Scheuring, S., Remigy, H., Braun, T., Mitsuoka, K., Fujiyoshi, Y., Engel, A.

FEBS Lett 504(3), 166-72 (2001)

PubMed

20

The aquaporin sidedness revisited

Scheuring, S., Tittmann, P., Stahlberg, H., Ringler, P., Borgnia, M., Agre, P., Gross, H., Engel, A.

J. Mol. Biol. 299(5), 1271-1278 (2000)

PubMed

19

GlpF: A structural variant of the aquaporin tetramer

Braun, T., Philippsen, A., Wirtz, S., Borgnia, J., Agre, P., Kühlbrandt, W., Engel, A., Stahlberg, H.

In `Molecular biology and physiology of water and solute transport`, Hohmann & S. Nielsen (Eds.) Kluwer Academic, New York. ISBN 0-306-46501-9 , 13-22 (2000)

18

Proton-powered turbine of a plant motor

Seelert, H., Poetsch, A., Dencher, N. A., Engel, A., Stahlberg, H., Muller, D. J.

Nature 405(6785), 418-9 (2000)

PubMed

17

Surface tongue-and-groove contours on lens MIP facilitate cell-to-cell adherence

Fotiadis, D., Hasler, L., Muller, D. J., Stahlberg, H., Kistler, J., Engel, A.

J Mol Biol 300(4), 779-89 (2000)

PubMed

16

The 3.7 Å projection map of the glycerol facilitator GlpF: a variant of the aquaporin tetramer

Braun, T., Philippsen, A., Wirtz, S., Borgnia, M. J., Agre, P., Kühlbrandt, W., Engel, A., Stahlberg, H.

EMBO Rep 1(2), 183-9 (2000)

PubMed

15

The 6.9-Å structure of GlpF: a basis for homology modeling of the glycerol channel from Escherichia coli

Stahlberg, H., Braun, T., de Groot, B., Philippsen, A., Borgnia, M. J., Agre, P., Kühlbrandt, W., Engel, A.

J Struct Biol 132(2), 133-41 (2000)

PubMed

14

Domain structure of secretin PulD revealed by limited proteolysis and electron microscopy

Nouwen, N., Stahlberg, H., Pugsley, A. P., Engel, A.

EMBO J 19(10), 2229-36 (2000)

PubMed

13

The reaction centre from green sulphur bacteria Chlorobium tedium: a structural analysis by scanning transmission electron microscopy

Remigy, H. W., Stahlberg, H., Fotiadis, D., Müller, S., Wolpensinger, B., Engel, A., Hauska, G., Tsiotis, G.

J Mol Biol 290(4), 851-858 (1999)

PubMed

12

Electron Cryomicroscopy

Dubochet, J., Stahlberg, H.

eLS - Enceclopedia of Life Sciences (online library), (2001)

DOI: 10.1038/npg.els.0002999

11

Structural investigation of the major intrinsic protein of lens fiber cell membranes

Hasler, L., Fotiadis, D., Müller, D.J., Kistler, J., Engel, A., Stahlberg, H.

Biophysical Journal 76(1), A136 (1999)

10

Structure of the water channel AqpZ from Escherichia coli revealed by electron crystallography

Ringler, P., Borgnia, M. J., Stahlberg, H., Maloney, P. C., Agre, P., Engel, A.

J Mol Biol 291(5), 1181-90 (1999)

PubMed

9

High resolution AFM topographs of the Escherichia coli water channel aquaporin Z

Scheuring, S., Ringler, P., Borgnia, M., Stahlberg, H., Muller, D. J., Agre, P., Engel, A.

EMBO J 18(18), 4981-7 (1999)

PubMed

8

Mitochondrial Lon of Saccharomyces cerevisiae is a ring-shaped protease with seven flexible subunits

Stahlberg, H., Kutejova, E., Suda, K., Wolpensinger, B., Lustig, A., Schatz, G., Engel, A., Suzuki, C. K.

Proc Natl Acad Sci U S A 96(12), 6787-90 (1999)

PubMed

7

The reaction centre of the photounit of Rhodospirillum rubrum is anchored to the light-harvesting complex with four-fold rotational disorder

Stahlberg, H., Dubochet, J., Vogel, H., Ghosh, R.

Photosynthesis Research 55, 363-368 (1998)

6

Are the light-harvesting I complexes from Rhodospirillum rubrum arranged around the reaction centre in a square geometry?

Stahlberg, H., Dubochet, J., Vogel, H., Ghosh, R.

J Mol Biol 282(4), 819-31 (1998)

PubMed

5

Friction anisotropy and asymmetry of a compliant monolayer induced by a small molecular tilt

Liley, M., Gourdon, D., Stamou, D., Meseth, U., Fischer, T. M., Lautz, C., Stahlberg, H., Vogel, H., Burnham, N. A., Duschl, C.

Science 280(5361), 273-5 (1998)

PubMed

4

Chloroplast F0F1 ATP synthase imaged by atomic force microscopy

Neff, D., Tripathi, S., Middendorf, K., Stahlberg, H., Butt, H. J., Bamberg, E., Dencher, N. A.

J Struct Biol 119(2), 139-48 (1997)

PubMed

3

Sulphur-bearing lipids for the covalent attachment of supported lipid bilayers to gold surfaces: a detailed characterisation and analysis

Duschl, C., Liley, M., Lang, J, Ghandi, A., Zakeeruddin, S.M., Stahlberg, H., Dubochet, J., Nemetz, A., Knoll, W., Vogel, H.

Materials Science & Engineering C 4, 7-18 (1996)

2

2D thiolipid crystals examined by dark field transmission electron microscopy

Stahlberg, H., Duschl, C., Liley, M., Vogel, H., Dubochet, J.

Electron Microscopy 3A, 971-972 (1994)

1